12/14/2023 0 Comments Type 2 narcolepsy treatmentThe purpose of this study is to provide access to treatment with pitolisant while a U.S. Jacksonville, FL Rochester, MN Scottsdale/Phoenix, AZ with Excessive Daytime Sleepiness Associated with Narcolepsy with or without Cataplexy A Study to Provide Treatment with Pitolisant to Adult Patients in the U.S.The purpose of this study is to assess the safety and effectiveness of AXS-12 in narcoleptic subjects with cataplexy and excessive daytime sleepiness (EDS). To assess the role of infection and other triggering factors in early onset Narcolepsy. The purpose of this study is to evaluate the clinical presentations, polysomnographic features, treatment patterns of all children with narcolepsy in multiple CTSA (Clinical and Translational Science Award) centers.Comparison between recent cases (2009-June 30, 2012) and old cases (prior to 2009) will be performed. The purpose of this study is to assess the safety and efficacy of AXS-12 in narcoleptic subjects with cataplexy and excessive daytime sleepiness (EDS). A Study to Assess the Efficacy and Safety of AXS-12 (Reboxetine) in Patients With Narcolepsy.Interview 1 will consist of a concept elicitation (CE). The interviews will be conducted via telephone, or face-to-face using a web-assisted platform. The interviews will be semi-structured, using a discussion guide, and all will be conducted by a trained interviewer. Each participant will take part in two interviews each interview will last approximately 75 minutes, and interviews will be completed within seven days of each other. All interviews will be undertaken in the United States (US). This study will involve in-depth, qualitative interviews with adults who have a diagnosis of NT2 (N = 15), who meet the agreed inclusion/exclusion criteria. A Study to Analyze Concept Elicitation and Content Validation for Narcolepsy Type 2 and Idiopathic Hypersomnia.Hypersomnia also occurs in patients with meningoencephalitis due to African trypanosomiasis (sleeping sickness), which is transmitted by the tsetse fly. Acute, relatively brief EDS and hypersomnia commonly accompany acute systemic disorders such as influenza. read more can also cause EDS with or without hypersomnia. read more, and seizure disorders Seizure Disorders A seizure is an abnormal, unregulated electrical discharge that occurs within the brain’s cortical gray matter and transiently interrupts normal brain function. Cardinal manifestations are jaundice, coagulopathy, and encephalopathy. read more, hepatic failure Acute Liver Failure Acute liver failure is caused most often by drugs and hepatitis viruses. Principal causes include hyperparathyroidism. read more, hypercalcemia Hypercalcemia Hypercalcemia is a total serum calcium concentration > 10.4 mg/dL (> 2.60 mmol/L) or ionized serum calcium > 5.2 mg/dL (> 1.30 mmol/L). read more, anemia, uremia, hypercapnia Ventilatory Failure Ventilatory failure is a rise in PaCO2 (hypercapnia) that occurs when the respiratory load can no longer be supported by the strength or activity of the system. In patients with diabetes who take insulin or antihyperglycemic. read more, hyperglycemia, hypoglycemia Hypoglycemia Hypoglycemia, or low plasma glucose level can result in sympathetic nervous system stimulation, and central nervous system dysfunction. Signs may include a typical facial appearance, hoarse slow speech, and dry skin. Symptoms include cold intolerance, fatigue, and weight gain. Hypothyroidism Hypothyroidism Hypothyroidism is thyroid hormone deficiency. These disorders include space-occupying lesions affecting the hypothalamus or upper brain stem, increased intracranial pressure, and certain forms of encephalitis. Other disorders that can cause chronic EDS are usually suggested by the history and physical examination brain imaging and blood and urine tests can confirm the diagnosis.
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